Faculty members located in academic
departments/centers can be formally associated with the IGBB in two
different ways:
1. IGBB Fellows
Through its Fellows Program, the
IGBB rewards those faculty who have worked within the IGBB to build a
strong, vibrant molecular biosciences/computational biology research
community at MS State. IGBB Fellows receive not only formal recognition
for their accomplishments, but they are given a voice in many aspects of
IGBB operation including, but not limited to, input on purchases, new hires,
and overall research direction. The IGBB Fellows literally serve as
the Director's Advisory Committee. To be an IGBB Fellow, a faculty member from an academic department
must (1) regularly submit proposals through the IGBB, (2) have had at least one funded external grant (with overhead)
administered through the IGBB, (3) have a record of high-impact scientific
productivity, and (4) have a national/international reputation in his/her
field. IGBB Fellows have full "internal user" access to the HPC² supercomputers and receive HPC²
computer, technical, and administrative support.
2. IGBB Faculty Affiliates
An IGBB Faculty Affiliate is any faculty member in an MS State academic department who (1) conducts research
in the molecular biosciences and/or computational biology and (2) collaborates in some manner with IGBB faculty/staff. Like IGBB Fellows, IGBB Faculty Affiliates are encouraged to submit proposals through the IGBB, but
are not obligated to do so. IGBB Faculty Affiliates generally do not
have HPC² supercomputer access unless they are working on an IGBB
research project. Faculty Affiliates can request access to the HPC²
supercomputers if they are interested in generating data/results for an eventual proposal submission
through the IGBB. Any IGBB Faculty Affiliate that submits and receives an external grant (with
overhead) through the IGBB will be eligible for the IGBB Fellows Program.

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases
IGBB Authors:
Mariola J. EdelmannPUBLICATION YEAR:
2011IMPACT FACTOR:
7.093CITATION COUNT:
93Edelmann MJ, Nicholson B, Kessler BM (2011) Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.
Expert Reviews in Molecular Medicine 13: e35.
DOI:
10.1017/S1462399411002031EID:
2-s2.0-84857085837PMID: 22088887
DOWNLOAD PDFABSTRACTRecent advances in the development and discovery of pharmacological interventions within the ubiquitin-proteasome system (UPS) have uncovered an enormous potential for possible novel treatments of neurodegenerative disease, cancer, immunological disorder and microbial infection. Interference with proteasome activity, although initially considered unlikely to be exploitable clinically, has already proved to be very effective against haematological malignancies, and more specific derivatives that target subsets of proteasomes are emerging. Recent small-molecule screens have revealed inhibitors against ubiquitin-conjugating and -deconjugating enzymes, many of which have been evaluated for their potential use as therapeutics, either as single agents or in synergy with other drugs. Here, we discuss recent advances in the characterisation of novel UPS modulators (in particular, inhibitors of ubiquitin-conjugating and -deconjugating enzymes) and how they pave the way towards new therapeutic approaches for the treatment of proteotoxic disease, cancer and microbial infection.
Dr. Daniel G. Peterson
Professor and Dept. Head
IGBB Fellow
(662) 325-3200
Dr. Matthew W. Brown
Associate Professor
IGBB Fellow
(662) 325-2406
Dr. Bindu Nanduri
Professor
IGBB Fellow
(662) 325-4217
Dr. Zhaohua Peng
Professor
IGBB Fellow
(662) 325-0685
Dr. Hossam Abdelhamed
Assistant Research Professor
IGBB Affiliate
(662) 325-1125
Dr. Pratima Acharya Adhikari
Assistant Professor
IGBB Affiliate
(662) 325-3416
Dr. Peter J. Allen
Professor
IGBB Affiliate
(662) 325-4768
Dr. Ashli Brown
Professor
IGBB Affiliate
(662) 325-3324
Dr. Sam Chang
Professor
IGBB Affiliate
(662) 325-3200
Dr. Sandra B. Correa
Assistant Professor
IGBB Affiliate
(662) 325-0158
Dr. Angus Dawe
Professor
IGBB Affiliate
(662) 325-7577
Dr. Peixin Fan
Assistant Professor
IGBB Affiliate
(662) 325-0963
Dr. Jean M.N. Feugang
Associate Research Professor
IGBB Affiliate
(662) 325-7567
Dr. Christine Fortuin
Assistant Professor
IGBB Affiliate
(662) 325-0282
Dr. Federico G. Hoffmann
Associate Professor
IGBB Affiliate
(662) 325-2763
Dr. Attila Karsi
Professor
IGBB Affiliate
(662) 325-0405
Dr. Margaret L. Khaitsa
Professor
IGBB Affiliate
(662) 325-1365
Dr. William Kingery
Professor
IGBB Affiliate
(662) 325-2311
Dr. Andrew Kouba
Professor
IGBB Affiliate
(662) 325-2378
Dr. Natraj (Krish) Krishnan
Associate Professor
IGBB Affiliate
(662) 325-2978
Dr. Mark Lawrence
Professor
IGBB Affiliate
(662) 325-1205
Dr. Caleb Lemley
Associate Professor
IGBB Affiliate
(662) 325-2934
Dr. Shien Lu
Professor
IGBB Affiliate
(662) 325-3511
Dr. Benjamin Magbanua
Associate Professor
IGBB Affiliate
(662) 325-9777
Dr. Florencia Meyer
Associate Professor
IGBB Affiliate
(662) 325-7734
Dr. Ramakrishna (Rama) Nannapaneni
Research Professor
IGBB Affiliate
(662) 325-7697
Dr. Diana Outlaw
Associate Professor
IGBB Affiliate
(662) 325-4803
Dr. E. David Peebles
Professor
IGBB Affiliate
(662) 325-3379
Dr. Andy Perkins
Professor
IGBB Affiliate
(662) 325-0004
Dr. Lauren Priddy
Assistant Professor
IGBB Affiliate
(662) 325-5988
Dr. K. Raja Reddy
Research Professor
IGBB Affiliate
(662) 325-9463
Dr. Leyla Rios de Alvarez
Assistant Professor
IGBB Affiliate
(662) 325-2802
Dr. Sejo Sabanadzovic
Professor
IGBB Affiliate
(662) 325-9322
Dr. Michael Sandel
Assistant Professor
IGBB Affiliate
(662) 325-3133
Dr. Wes Schilling
Professor
IGBB Affiliate
(662) 325-9456
Dr. Keun-Seok Seo
Associate Professor
IGBB Affiliate
(662) 325-1419
Dr. Xueyan Shan
Associate Research Professor
IGBB Affiliate
(662) 325-2640
Dr. Rubin Shmulsky
Professor
IGBB Affiliate
(662) 325-2243
Dr. Juan L. Silva
Professor
IGBB Affiliate
(662) 325-3200
Dr. C. Beth Stokes
Associate Professor
IGBB Affiliate
(662) 325-5811
Dr. Justin Thornton
Associate Professor
IGBB Affiliate
(662) 325-8020
Dr. Te-Ming (Paul) Tseng
Associate Professor
IGBB Affiliate
(662) 325-4725
Dr. Carrie Vance
Associate Research Professor
IGBB Affiliate
(662) 325-2640
Dr. Guiming Wang
Professor
IGBB Affiliate
(662) 325-0414
Dr. Mark Welch
Professor
IGBB Affiliate
(662) 325-7564
Dr. Li Zhang
Assistant Research Professor
IGBB Affiliate
(662) 325-3416
Dr. Xue Zhang
Assistant Research Professor
IGBB Affiliate
(662) 325-3200
Former Fellows & Affiliates (Position with IGBB; Current Institution)
- Wen-Hsing Cheng (Affiliate; Texas Woman's University)
- Thu Dinh (Affiliate; Tyson Foods)
- Esteban Galeano (Affiliate; Weyerhaeuser)
- Austin Himes (Affiliate; Washington State University)
- Dr. Sorina Popescu (Affiliate; Retired)
- Dr. Stephen B. Pruett (Affiliate; Retired)
- Dr. John Riggins (Affiliate; Oregon State University)
- Jeffrey F.D. Dean (Affiliate; University of Georgia)
- Jonas King (Affiliate)
- Hongxu Dong (Affiliate; Goldman Sachs, Atlanta)
- Terezie Tolar-Peterson (Affiliate; California State University, San Bernadino)
- Erdogan Memili (Affiliate; Prairie View A&M University)
- Gregory Bohach (Affiliate; Retired)
- Brian A. Counterman (Affiliate; Auburn University)
- Renita Horton (Affiliate; University of Houston)
- Xiu-feng "Henry" Wan (Affiliate; University of Missouri)
- Din-Pow Ma (Affiliate; Retired)
- David A. Ray (Fellow; Texas Tech University)
- Shane C. Burgess (Fellow & former IGBB Director; University of Arizona)
- Fiona M. McCarthy (Fellow; University of Arizona)
- Susan M. Bridges (Fellow; Retired)
- Susan V. Diehl (Affiliate; Retired)
- James N. Warnock (Affiliate; University of Georgia)
- Dragica Jeremic Nikolic (Affiliate; University of Toronto)
- Cetin Yuceer (Affiliate; Turkey)
The IGBB is supported, in part, by the following units:
The IGBB is an HPC² member center.