Faculty members located in academic
departments/centers can be formally associated with the IGBB in two
different ways:
1. IGBB Fellows
Through its Fellows Program, the
IGBB rewards those faculty who have worked within the IGBB to build a
strong, vibrant molecular biosciences/computational biology research
community at MS State. IGBB Fellows receive not only formal recognition
for their accomplishments, but they are given a voice in many aspects of
IGBB operation including, but not limited to, input on purchases, new hires,
and overall research direction. The IGBB Fellows literally serve as
the Director's Advisory Committee. To be an IGBB Fellow, a faculty member from an academic department
must (1) regularly submit proposals through the IGBB, (2) have had at least one funded external grant (with overhead)
administered through the IGBB, (3) have a record of high-impact scientific
productivity, and (4) have a national/international reputation in his/her
field. IGBB Fellows have full "internal user" access to the HPC² supercomputers and receive HPC²
computer, technical, and administrative support.
2. IGBB Faculty Affiliates
An IGBB Faculty Affiliate is any faculty member in an MS State academic department who (1) conducts research
in the molecular biosciences and/or computational biology and (2) collaborates in some manner with IGBB faculty/staff. Like IGBB Fellows, IGBB Faculty Affiliates are encouraged to submit proposals through the IGBB, but
are not obligated to do so. IGBB Faculty Affiliates generally do not
have HPC² supercomputer access unless they are working on an IGBB
research project. Faculty Affiliates can request access to the HPC²
supercomputers if they are interested in generating data/results for an eventual proposal submission
through the IGBB. Any IGBB Faculty Affiliate that submits and receives an external grant (with
overhead) through the IGBB will be eligible for the IGBB Fellows Program.

Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility
IGBB Authors:
Bindu Nanduri, Jean-Magloire Nguekam Feugang, Shane C. Burgess, Erdogan MemiliPUBLICATION YEAR:
2008IMPACT FACTOR:
3.105CITATION COUNT:
170Peddinti DS, Nanduri B, Kaya A, Feugang JM, Burgess SC, Memili E (2008) Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility.
BMC Systems Biology 2: 19.
DOI:
10.1186/1752-0509-2-19EID:
2-s2.0-42049123062PMID: 18294385
DOWNLOAD PDFABSTRACTBACKGROUND: Male infertility is a major problem for mammalian reproduction. However, molecular details including the underlying mechanisms of male fertility are still not known. A thorough understanding of these mechanisms is essential for obtaining consistently high reproductive efficiency and to ensure lower cost and time-loss by breeder. RESULTS: Using high and low fertility bull spermatozoa, here we employed differential detergent fractionation multidimensional protein identification technology (DDF-Mud PIT) and identified 125 putative biomarkers of fertility. We next used quantitative Systems Biology modeling and canonical protein interaction pathways and networks to show that high fertility spermatozoa differ from low fertility spermatozoa in four main ways. Compared to sperm from low fertility bulls, sperm from high fertility bulls have higher expression of proteins involved in: energy metabolism, cell communication, spermatogenesis, and cell motility. Our data also suggests a hypothesis that low fertility sperm DNA integrity may be compromised because cell cycle: G2/M DNA damage checkpoint regulation was most significant signaling pathway identified in low fertility spermatozoa. CONCLUSION: This is the first comprehensive description of the bovine spermatozoa proteome. Comparative proteomic analysis of high fertility and low fertility bulls, in the context of protein interaction networks identified putative molecular markers associated with high fertility phenotype.
Dr. Matthew W. 
BrownAssistant Professor
IGBB Fellow
website (662) 325-2406
Dr. Bindu 
NanduriAssociate Professor
IGBB Fellow
website (662) 325-4217
Dr. Zhaohua 
PengProfessor
IGBB Fellow
website (662) 325-0685
Dr. Hossam 
AbdelhamedAssistant Research Professor
IGBB Affiliate
website (662) 325-1125
Dr. Pratima 
Acharya AdhikariAssistant Professor
IGBB Affiliate
website (662) 325-3416
Dr. Peter J. 
AllenAssociate Professor
IGBB Affiliate
website (662) 325-4768
Dr. Gregory 
BohachProfessor
IGBB Affiliate
(662) 325-3006
Dr. Ashli 
Brown JohnsonAssociate Professor & State Chemist
IGBB Affiliate
website (662) 325-3324
Dr. Sam 
ChangProfessor
IGBB Affiliate
website (662) 325-3200
Dr. Wen-Hsing 
ChengAssociate Professor
IGBB Affiliate
website (662) 325-3200
Dr. Brian 
CountermanAssociate Professor
IGBB Affiliate
website (662) 325-4824
Dr. Angus 
DaweProfessor & Head
IGBB Affiliate
website (662) 325-7577
Dr. Jeffrey 
DeanProfessor & Head
IGBB Affiliate
website (662) 325-2640
Dr. Thu 
DinhAssistant Professor
IGBB Affiliate
website (662) 325-7554
Dr. Jean M.N. 
FeugangAssistant Research Professor
IGBB Affiliate
website (662) 325-7567
Dr. Federico G. 
HoffmannAssistant Professor
IGBB Affiliate
website (662) 325-2763
Dr. Attila 
KarsiAssociate Professor
IGBB Affiliate
website (662) 325-0405
Dr. Margaret L. 
KhaitsaProfessor
IGBB Affiliate
website (662) 325-1365
Dr. Jonas 
KingAssistant Professor
IGBB Affiliate
website (662) 325-7740
Dr. William 
KingeryProfessor
IGBB Affiliate
website (662) 325-2311
Dr. Natraj (Krish) 
KrishnanAssistant Professor
IGBB Affiliate
website (662) 325-2978
Dr. Mark 
LawrenceProfessor & Associate Dean
IGBB Affiliate
website (662) 325-1205
Dr. Shien 
LuAssociate Professor
IGBB Affiliate
website (662) 325-3511
Dr. Erdogan 
MemiliAssociate Professor
IGBB Affiliate
website (662) 325-2937
Dr. Florencia 
MeyerAssistant Professor
IGBB Affiliate
website (662) 325-7734
Dr. Ramakrishna (Rama) 
NannapaneniAssociate Research Professor
IGBB Affiliate
website (662) 325-7697
Dr. Diana 
OutlawAssociate Professor
IGBB Affiliate
website (662) 325-4803
Dr. E. David 
PeeblesProfessor
IGBB Affiliate
website (662) 325-3379
Dr. Andy 
PerkinsAssociate Professor
IGBB Affiliate
website (662) 325-0004
Dr. Sorina 
PopescuAssistant Professor
IGBB Affiliate
website (662) 325-7735
Dr. Lauren 
PriddyAssistant Professor
IGBB Affiliate
website (662) 325-5988
Dr. Stephen B. 
PruettInterim Assoc. Dean & Professor
IGBB Affiliate
website (662) 325-6653
Dr. K. Raja 
ReddyResearch Professor
IGBB Affiliate
website (662) 325-9463
Dr. John 
RigginsAssociate Professor
IGBB Affiliate
website (662) 325-2984
Dr. Sejo 
SabanadzovicProfessor
IGBB Affiliate
website (662) 325-9322
Dr. Wes 
SchillingProfessor
IGBB Affiliate
website (662) 325-9456
Dr. Keun-Seok 
SeoAssociate Professor
IGBB Affiliate
website (662) 325-1419
Dr. Xueyan 
ShanAssistant Research Professor
IGBB Affiliate
website (662) 325-2640
Dr. Rubin 
ShmulskyProfessor & Head
IGBB Affiliate
website (662) 325-2243
Dr. Juan L. 
SilvaProfessor
IGBB Affiliate
website (662) 325-3200
Dr. C. Beth 
StokesAssistant Professor
IGBB Affiliate
website (662) 325-5811
Dr. Justin 
ThorntonAssociate Professor
IGBB Affiliate
website (662) 325-8020
Dr. Terezie 
Tolar-PetersonAssistant Professor
IGBB Affiliate
website (662) 325-5902
Dr. Te-Ming (Paul) 
TsengAssistant Professor
IGBB Affiliate
website (662) 325-4725
Dr. Mark 
WelchAssociate Professor
IGBB Affiliate
website (662) 325-7564
Dr. Li 
ZhangAssistant Research Professor
IGBB Affiliate
website (662) 325-3416
Former Fellows & Affiliates (Position with IGBB; Current Institution)
Renita Horton (Affiliate; University of Houston)
Xiu-feng "Henry" Wan (Affiliate; University of Missouri)
Din-Pow Ma (Affiliate; retired)
David A. Ray (Fellow; Texas Tech University)
Shane C. Burgess (Fellow & former IGBB Director; University of Arizona)
Fiona M. McCarthy (Fellow; University of Arizona)
Susan M. Bridges (Fellow; University of Alabama in Huntsville)
Susan V. Diehl (Affiliate; retired)
James N. Warnock (Affiliate; University of Georgia)
Dragica Jeremic Nikolic (Affiliate; University of Toronto)
Cetin Yuceer (Affiliate; Turkey)
The IGBB is supported, in part, by the following units:
The IGBB is an HPC² member center.