The IGBB logo features a stylized "pinwheel" to the left of the letters IGBB in caps in a modified Bank Gothic Pro font.
The six-part "pinwheel" in the IGBB logo is:
- A symbol of lab unity as it shows "parts" coming together to make a "whole."
- A flower or three-leaf clover representing (a) plants, important subjects of our research, (b) life in general, and (c) the life sciences (biology).
- A set of chromosomes being moved towards the center of a cell.
- The Sun - another symbol of life.
- A protein composed of six subunits (e.g., a protein pore).
- Three foxes putting their heads together. The fox is a symbol of cleverness in Western folklore. Since the IGBB is organized into three service groups (Genomics, Proteomics/Metabolomics, and Biocomputing/Computational Biology), the foxes could represent the three disciplines working together.
- A scientist jumping for joy after making an important discovery.
- A windmill, the primary symbol associated with Cervantes' famous character Don Quixote - Like Don Quixote, scientists must be willing to attack 'wicked giants' (e.g., ignorance, racism, sexism, intolerance, use of the term 'science' in the promotion of non-scientific causes), champion worthy causes (e.g., education, intellectual freedom, human rights, environmental responsibility), and remain optimistic in the face of defeat (e.g., most days in the lab). Hopefully, however, the average scientist can accomplish these tasks without becoming delusional (a problem that squashed Quixote's dreams of becoming a plant molecular biologist).
- A DNA double-helix or protein in cross section.
- Antibodies binding to a protein.
- Whatever you want it to be.
Dr. Charles A. Thrash (Adam)Computer Specialist
BIOCOMPUTING
emailn/a
Knoxville, TN
Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain
IGBB Authors:
Shane C. BurgessPUBLICATION YEAR:
2006IMPACT FACTOR:
3.235CITATION COUNT:
72Betancourt AM, Burgess SC, Carr RL (2006) Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain.
Toxicological Sciences 92(2): 500-506.
DOI:
10.1093/toxsci/kfl004EID:
2-s2.0-33745775656PMID: 16675515
DOWNLOAD PDFABSTRACTChlorpyrifos (CPS), a known neurotoxicant, is a widely used agricultural organophosphorus insecticide. The effects of postnatal exposure to CPS on the expression of mRNA for two factors critical to brain development, nerve growth factor (NGF) and reelin, were investigated in the forebrain of rats. In addition, the expression of mRNA for the muscarinic acetylcholine receptor (mAChR) M(1) subtype and cell-specific markers for developing neurons (beta-III tubulin), astrocytes (glial fibrillary acidic protein, GFAP), and oligodendrocytes (myelin-associated glycoprotein, MAG) was also investigated. Oral administration of CPS (1.5 or 3.0 mg/kg) or the corn oil vehicle was performed daily from postnatal days (PNDs) 1 through 6. No signs of overt toxicity or of cholinergic hyperstimulation were observed after CPS administration. Body weight was significantly different from controls on PND7 in both males and females exposed to 3.0 mg/kg CPS. Quantitative PCR was performed on the forebrain. The expression of NGF, reelin, and M(1) mAChR mRNA was significantly reduced with both dosages of CPS in both sexes. beta-III Tubulin mRNA expression remained unchanged after exposure, whereas MAG mRNA expression was significantly decreased with both dosages of CPS in both sexes, suggesting effects on the developing oligodendrocytes. In contrast, GFAP mRNA levels were significantly increased with both dosages of CPS in both sexes, suggesting increased astrocyte reactivity. Our findings indicate that dosages of CPS which cause significant cholinesterase inhibition but do not exert overt toxicity can adversely affect the expression levels of critical genes involved in brain development during the early postnatal period in the rat.
The IGBB is supported, in part, by the following units:
The IGBB is an HPC² member center.
