All Fields Required Unless Otherwise Stated
After registering, your account on the IGBB system will be ready to use. By default, you will be identified as an external user (non-MSU Employee).
If you are an MSU employee and you are interested in purchasing services from IGBB, your account type can be updated by IGBB personnel.
Topic:
Gene networks
IGBB Scientists:
George Popescu
Sorina Popescu
Funding:
USDA

Predictable convergence in hemoglobin function has unpredictable molecular underpinnings
IGBB Authors:
Federico G. HoffmannPUBLICATION YEAR:
2016IMPACT FACTOR:
19.87CITATION COUNT:
176Natarajan C, Hoffmann FG, Weber RE, Fago A, Witt CC, Storz JF (2016) Predictable convergence in hemoglobin function has unpredictable molecular underpinnings.
Science 354(6310): 336-339.
DOI:
10.1126/science.aaf9070EID:
2-s2.0-84992153922PMID: 27846568
DOWNLOAD PDFABSTRACTTo investigate the predictability of genetic adaptation, we examined the molecular basis of convergence in hemoglobin function in comparisons involving 56 avian taxa that have contrasting altitudinal range limits. Convergent increases in hemoglobin-oxygen affinity were pervasive among high-altitude taxa, but few such changes were attributable to parallel amino acid substitutions at key residues. Thus, predictable changes in biochemical phenotype do not have a predictable molecular basis. Experiments involving resurrected ancestral proteins revealed that historical substitutions have context-dependent effects, indicating that possible adaptive solutions are contingent on prior history. Mutations that produce an adaptive change in one species may represent precluded possibilities in other species because of differences in genetic background. © 2016, American Association for the Advancement of Science. All rights reserved.


Dr. E. David PeeblesProfessor
Poultry ScienceIGBB Affiliate
email(662) 325-3379
Dr. Te-Ming (Paul) TsengAssociate Professor
Plant & Soil SciencesIGBB Affiliate
email(662) 325-4725
Dr. Charles A. Thrash (Adam)Computer Specialist
BIOCOMPUTING
emailn/a
Knoxville, TN
The IGBB is supported, in part, by the following units:
The IGBB is an HPC² member center.