Owen MPT, Northrop EJ, Rich JJJ, Perry GA, Messman RD, Dinh TTN, McCarty KJ, Yang J, Wan D, Lemley CO (2020) Oxylipin concentrations in bovine corpora lutea during maternal recognition of pregnancy. Theriogenology 142: 384-389.
Zeng H, Larson KJ, Cheng W-H, Bukowski MR, Safratowich BD, Liu Z, Hakkak R (2020) Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. Journal of Nutritional Biochemistry 78: 108336.
Ishak GM, Dutra GA, Gastal GDA, Elcombe ME, Gastal MO, Park SB, Feugang JM, Gastal EL (2020) Deficiency in proliferative, angiogenic, and LH receptors in the follicle wall: implications of season toward the anovulatory condition. Domestic Animal Endocrinology 70: 106382.
Dinken CP, Keretz KR, Schramm HL, Jr, Petrie-Hanson L, Wes Schilling M, Allen PJ (2020) Changes in Physiology and Stress Responses of Pellet-Reared Largemouth Bass Fed Live-Forage Diets. North American Journal of Aquaculture 82(1): 3-23.
Moss JB, Gerber GP, Goetz M, Haakonsson JE, Harvey JC, Laaser T, Welch ME (2020) Contrasting Patterns of Movement across Life Stages in an Insular Iguana Population. Journal of Herpetology 54(1): 67-77.
Rycroft TE, Foran CM, Thrash A, Cegan JC, Zollinger R, Linkov I, Perkins EJ, Garcia-Reyero N (2020) AOPERA: A proposed methodology and inventory of effective tools to link chemicals to adverse outcome pathways. ALTEX 37(1): 64-74.
New approaches, like the Adverse Outcome Pathway (AOP) framework, have been developed to describe how chemicals cause toxicity by linking in vitro assays to adverse health outcomes. However, approaches, tools and resources for development of AOPs have not been well described. Here we review information resources for AOP development and define a streamlined process for linking a chemical to an existing AOP. We propose a four step process to facilitate AOP development: link the uncharacterized chemical directly to Molecular Initiating Events, Key Events, or Adverse Outcomes; identify analogs with toxicological information for the uncharacterized chemical; link the characterized chemical (initial chemical if characterized, a characterized analog if initial chemical is not) to Molecular Initiating Events, Key Events, or Adverse Outcomes; and identify AOPs that contain the Molecular Initiating Events, Key Events, or Adverse Outcomes that were found in Steps 1 and 3. The process and library of informational resources proposed and tested here served as the foundation for an informational online tool (AOPERA) that helps practitioners identify their current-state knowledge gaps, navigate the four-step process, and connect to relevant resources. AOPERA can be found at https://igbb.github.io/AOPERA_HTML. Additionally, we anticipate that by simplifying and standardizing the process of linking a chemical to a known AOP, we will lower the barrier to entry for this objective and increase its accessibility to new practitioners. In turn, this may increase the demand for new or improved AOPs to which practitioners can link chemicals, thereby contributing to the expansion of the library of known AOPs.
Zhao D, Kogut MH, Genovese KJ, Hsu C-Y, Lee JT, Farnell YZ (2020) Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast. Poultry Science 99(1): 11-20.
Sokale AO, Williams CJ, Triplett MD, Hoerr FJ, Peebles ED (2020) Effects of stage of broiler embryo development on coccidiosis vaccine injection accuracy, and subsequent oocyst localization and hatchling quality. Poultry Science 99(1): 189-195.
Alugubelly N, Mohammad AN, Edelmann MJ, Nanduri B, Sayed M, Park JW, Carr RL (2019) Proteomic and transcriptional profiling of rat amygdala following social play. Behavioural Brain Research 376: 112210.