Physical Address
IGBB
Portera HPC Building
2 Research Boulevard
Starkville, MS 39759
Mailing Address
IGBB
Portera HPC Building
Box 9627
Mississippi State, MS 39762
Phone/Fax
Phone: 662-325-8278
Fax: 662-325-7692
We highly recommend that anyone wishing to contact the IGBB via the Internet/e-mail do so by submitting a HelpDesk ticket. Submitting a HelpDesk ticket ensures that your question is directed to the appropriate IGBB staff member(s) and is not left unanswered. In order to submit a HelpDesk ticket, you must first register for a free MyIGBB account. Registration is simple, takes less than a minute, and obligates you to absolutely nothing.
If you do not wish to use the IGBB HelpDesk, you may send an e-mail to one of the following IGBB employees: Dr. Olga Pechanova (Proteomics Lead), Dr. Chuan-Yu Hsu (Genomics Lead), Mr. Tony Arick (Computational Biology Lead), or Ms. Kelsey Stewart (Contract & Grant Specialist).
See Personnel for more contact names/numbers/e-mail addresses.
Adverse outcome pathway development II: Best practices
IGBB Authors:
Natàlia Garcia-ReyeroPUBLICATION YEAR:
2014IMPACT FACTOR:
5.023CITATION COUNT:
93Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M (2014) Adverse outcome pathway development II: Best practices.
Toxicological Sciences 142(2): 321-330.
DOI:
10.1093/toxsci/kfu200EID:
2-s2.0-84922465985PMID: 25466379
DOWNLOAD PDFABSTRACTOrganization of existing and emerging toxicological knowledge into adverse outcome pathway (AOP) descriptions can facilitate greater application of mechanistic data, including those derived through high-throughput in vitro, high content omics and imaging, and biomarker approaches, in risk-based decision making. The previously ad hoc process of AOP development is being formalized through development of internationally harmonized guidance and principles. The goal of this article was to outline the information content desired for formal AOP description and some rules of thumb and best practices intended to facilitate reuse and connectivity of elements of an AOP description in a knowledgebase and network context. For example, key events (KEs) are measurements of change in biological state that are indicative of progression of a perturbation toward a specified adverse outcome. Best practices for KE description suggest that each KE should be defined as an independent measurement made at a particular level of biological organization. The concept of "functional equivalence" can help guide both decisions about how many KEs to include in an AOP and the specificity with which they are defined. Likewise, in describing both KEs and evidence that supports a causal linkage or statistical association between them (ie, a key event relationship; KER), best practice is to build from and contribute to existing KE or KER descriptions in the AOP knowledgebase rather than creating redundant descriptions. The best practices proposed address many of the challenges and uncertainties related to AOP development and help promote a consistent and reliable, yet flexible approach. © The Author 2014.
Dr. Natraj (Krish) KrishnanAssistant Professor
Biochemistry, Molecular Biology, Entomology & Plant PathologyIGBB Affiliate
email(662) 325-2978
website
The IGBB is supported, in part, by the following units:
The IGBB is an HPC² member center.
