Physical Address
IGBB
Portera HPC Building
2 Research Boulevard
Starkville, MS 39759
Mailing Address
IGBB
Portera HPC Building
Box 9627
Mississippi State, MS 39762
Phone/Fax
Phone: 662-325-8278
Fax: 662-325-7692
We highly recommend that anyone wishing to contact the IGBB via the Internet/e-mail do so by submitting a HelpDesk ticket. Submitting a HelpDesk ticket ensures that your question is directed to the appropriate IGBB staff member(s) and is not left unanswered. In order to submit a HelpDesk ticket, you must first register for a free MyIGBB account. Registration is simple, takes less than a minute, and obligates you to absolutely nothing.
If you do not wish to use the IGBB HelpDesk, you may send an e-mail to one of the following IGBB employees: Dr. Olga Pechanova (Proteomics Lead), Dr. Chuan-Yu Hsu (Genomics Lead), Mr. Tony Arick (Computational Biology Lead), or Ms. Kelsey Stewart (Contract & Grant Specialist).
See Personnel for more contact names/numbers/e-mail addresses.
Review: Mechanobiology of the aortic heart valve
IGBB Authors:
James N. WarnockPUBLICATION YEAR:
2008IMPACT FACTOR:
1.118TIMES CITED (as of August 10, 2017):
CITATION PERCENTILE:
91Butcher JT, Simmons CA, Warnock JN (2008) Review: Mechanobiology of the aortic heart valve.
Journal of Heart Valve Disease 17(1): 62-73.
DOI:
EID:
ABSTRACTThe aortic heart valve is a complex and sophisticated structure that functions in a mechanically challenging environment. With each cardiac cycle, blood flow exerts shear stresses, bending stress and tensile and compressive forces on the valve tissue. These forces determine a plethora of biological responses, including gene expression, protein activation and cell phe-notype. Consequently, mechanical forces may influence valve remodeling or pathological changes. Understanding the mechanobiology of heart valves is a vast task. Herein, some of the recent studies that have increased current knowledge of endothelial and interstitial cell interactions with physical forces are examined. Additionally, experimental co-culture models are described that are being developed to further improve the understanding of endothelial-inter- stitial cell interactions. Finally, the means by which organ culture systems are being utilized to study heart valve biology, thereby providing a complementary approach to in vivo experimentation, are described.
Dr. Renita E. HortonAssistant Professor
Agricultural & Biological EngineeringIGBB Affiliate
email(662) 325-7345
website Dr. Andy PerkinsAssociate Professor
Computer Science & EngineeringIGBB Affiliate
email(662) 325-0004
website
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