Physical Address
IGBB
Portera HPC Building
2 Research Boulevard
Starkville, MS 39759
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IGBB
Portera HPC Building
Box 9627
Mississippi State, MS 39762
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Phone: 662-325-8278
Fax: 662-325-7692
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If you do not wish to use the IGBB HelpDesk, you may send an e-mail to one of the following IGBB employees: Dr. Olga Pechanova (Proteomics Lead), Dr. Chuan-Yu Hsu (Genomics Lead), Mr. Tony Arick (Computational Biology Lead), or Ms. Kelsey Stewart (Contract & Grant Specialist).
See Personnel for more contact names/numbers/e-mail addresses.
Predictable convergence in hemoglobin function has unpredictable molecular underpinnings
IGBB Authors:
Federico G. HoffmannPUBLICATION YEAR:
2016IMPACT FACTOR:
33.611TIMES CITED (as of August 10, 2017):
CITATION PERCENTILE:
98Natarajan C, Hoffmann FG, Weber RE, Fago A, Witt CC, Storz JF (2016) Predictable convergence in hemoglobin function has unpredictable molecular underpinnings.
Science 354(6310): 336-339.
DOI:
EID:
DOWNLOAD PDFABSTRACTTo investigate the predictability of genetic adaptation, we examined the molecular basis of convergence in hemoglobin function in comparisons involving 56 avian taxa that have contrasting altitudinal range limits. Convergent increases in hemoglobin-oxygen affinity were pervasive among high-altitude taxa, but few such changes were attributable to parallel amino acid substitutions at key residues. Thus, predictable changes in biochemical phenotype do not have a predictable molecular basis. Experiments involving resurrected ancestral proteins revealed that historical substitutions have context-dependent effects, indicating that possible adaptive solutions are contingent on prior history. Mutations that produce an adaptive change in one species may represent precluded possibilities in other species because of differences in genetic background. © 2016, American Association for the Advancement of Science. All rights reserved.
Dr. Bindu NanduriAssociate Professor
CVM Basic SciencesIGBB Fellow
email(662) 325-4217
website
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