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Mahesh ChinthalapudiGraduate Research Associate
GRADUATE STUDENT
email(701) 373 6012
458 Dorman Hall

Rerooting the evolutionary tree of malaria parasites
IGBB Authors:
Diana C. OutlawPUBLICATION YEAR:
2011IMPACT FACTOR:
10.425CITATION COUNT:
63Outlaw DC, Ricklefs RE (2011) Rerooting the evolutionary tree of malaria parasites.
Proceedings of the National Academy of Sciences of the United States of America 108(32): 13183-13187.
DOI:
10.1073/pnas.1109153108EID:
2-s2.0-80051960846PMID: 21730128
DOWNLOAD PDFABSTRACTMalaria parasites (Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of the diversification of malaria parasites from DNA sequences have suffered from uncertainty concerning outgroup taxa, limited taxon sampling, and selection on genes used to assess relationships. As a result, inferred relationships among the Haemosporida have been unstable, and questions concerning evolutionary diversification and host switching remain unanswered. A recent phylogeny placed mammalian malaria parasites, as well as avian/reptilian Plasmodium, in a derived position relative to the avian parasite genera Leucocytozoon and Haemoproteus, implying that the ancestral forms lacked merogony in the blood and that their vectors were non-mosquito dipterans. Bayesian, outgroup-free phylogenetic reconstruction using relaxed molecular clocks with uncorrelated rates instead suggested that mammalian and avian/reptilian Plasmodium parasites, spread by mosquito vectors, are ancestral sister taxa, from which a variety of specialized parasite lineages with modified life histories have evolved.
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