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Dr. Ramey C. Youngblood, Jr. (Cal)Senior Research Associate
GENOMICS
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Stoneville, MS
The histone methyltransferase SDG8 regulates shoot branching in Arabidopsis
IGBB Authors:
Din-Pow MaPUBLICATION YEAR:
2008IMPACT FACTOR:
3.019CITATION COUNT:
80Dong G, Ma DP,Li J (2008) The histone methyltransferase SDG8 regulates shoot branching in Arabidopsis.
Biochemical and Biophysical Research Communications 373(4): 659-64.
DOI:
10.1016/j.bbrc.2008.06.096EID:
2-s2.0-48949115063PMID: 18602372
DOWNLOAD PDFABSTRACTHistone lysine methylation is an evolutionally conserved modification involved in determining chromatin states associated with gene activation or repression. Here we report that the Arabidopsis SET domain group 8 (SDG8) protein is a histone H3 methyltransferase involved in regulating shoot branching. Knockout mutations of the SDG8 gene markedly reduce the global levels of histone H3 trimethylation at lysines 9 and 36 as well as dimethylation at lysine 36. The sdg8 mutants produce more shoot branches than wild-type plants. The expression of SPS/BUS (supershoot/bushy), a repressor of shoot branching, is decreased in sdg8 mutants, while UGT74E2 (UDP-glycosyltransferase 74E2), a gene associated with increased shoot branching, is up-regulated in sdg8 mutants. The altered expression of SPS/BUS and UGT74E2 correlates with changed histone H3 methylation at these loci. These results suggest that SDG8 regulates shoot branching via controlling the methylation states of its target genes.
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