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Dr. Shankar G. ShanmugamAssistant Research Professor
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Listeria monocytogenes subgroups IIIA, IIIB, and IIIC delineate genetically distinct populations with varied pathogenic potentialIGBB Authors:
Mark L. LawrencePUBLICATION YEAR:
2006IMPACT FACTOR:
4.019CITATION COUNT:
78Liu D, Lawrence ML, Wiedmann M, Gorski L, Mandrell RE, Ainsworth AJ, Austin FW (2006) Listeria monocytogenes subgroups IIIA, IIIB, and IIIC delineate genetically distinct populations with varied pathogenic potential.
Journal of Clinical Microbiology 44(11): 4229-4233.
DOI:
10.1128/JCM.01032-06EID:
2-s2.0-33750945680PMID: 17005751
DOWNLOAD PDFABSTRACTListeria monocytogenes lineage III strains belonging to subgroups IIIA (n=8), IIIB (n=5), and IIIC (n=6) were examined along with other known serotype strains (n=11) by PCR and Southern hybridization using several recently described species-, virulence-, and serotype-specific primers and probes. The virulence of seven representative lineage III strains was then evaluated in mice via the intraperitoneal route. The results suggest that subgroup IIIA consists of typical rhamnose-positive avirulent serotype 4a and virulent serotype 4c strains, subgroup IIIC consists of atypical rhamnose-negative virulent serotype 4c strains, and subgroup IIIB consists of atypical rhamnose-negative virulent non-serotype 4a and non-serotype 4c strains, some of which may be related to serotype 7. It is possible that subgroup IIIB (including serotype 7) may represent a novel subspecies within L. monocytogenes.
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