The IGBB is a member of the NIH-funded Mississippi IDeA Network of Biomedical Research Excellence (Mississippi INBRE or MS-INBRE), a program designed to build biomedical infrastructure throughout the state. Through MS-INBRE, Mississippi students and faculty at Mississippi's undergraduate institutions are (1) trained in biomedical research techniques, (2) given the opportunity to work with top researchers at Mississippi's major research universities, (3) afforded access to state-of-the-art bioscience equipment, and (4) provided with assistance in preparing grant proposals. The IGBB serves as the MS-INBRE proteomics/computational biology core. For more information about MS-INBRE, click here.
Characterization of malignant tissue cells by laser-induced breakdown spectroscopy
IGBB Authors:
Shane C. BurgessPUBLICATION YEAR:
2004IMPACT FACTOR:
1.594CITATION COUNT:
165Kumar A, Yueh FY, Singh JP, Burgess SC (2004) Characterization of malignant tissue cells by laser-induced breakdown spectroscopy.
Applied Optics 43(28): 5399-5403.
DOI:
10.1364/AO.43.005399EID:
2-s2.0-5444235054PMID: 15495432
DOWNLOAD PDFABSTRACTCancer diagnosis and classification is extremely complicated and, for the most part, relies on subjective interpretation of biopsy material. Such methods are laborious and in some cases might result in different results depending on the histopathologist doing the examination. Automated, real-time diagnostic procedures would greatly facilitate cancer diagnosis and classification. Laser-induced breakdown spectroscopy (LIBS) is used for the first time to our knowledge to distinguish normal and malignant tumor cells from histological sections. We found that the concentration of trace elements in normal and tumor cells was significantly different. For comparison, the tissue samples were also analyzed by an inductively coupled plasma emission spectroscopy (ICPES) system. The results from the LIBS measurement and ICPES analysis were in good agreement.
The IGBB is supported, in part, by the following units:
The IGBB is an HPC² member center.
